Name: m-Cresol
CAS Number: 108-39-4
UN Number: 2076
Formulae: C7H8O
Name: m-Cresol
CAS Number: 108-39-4
UN Number: 2076
Formulae: C7H8O
Physicochemical properties/Characteristics
-
SD
Physical behaviour (GESAMP, 2016)
1, 2 -
108.14
Molecular Weight
2
(g/mol) -
1.03
Density
2
(kg/L) -
0.01
Vapour pressure
2
(KPa; 25ºC) -
22200
Water solubility
2
(mg/L; 25ºC) -
16.9
Dynamic viscosity
2, 3
(mPa.s; 20ºC) -
11.8
Melting point (ºC)
2 -
202.2
Boiling point (ºC)
2 -
1762.0
Volatilization half-life (days)
4
- G: gas; D: dissolver; E: evaporator; F: floater; S: sinker; GD: gas/dissolver; DE: dissolver/evaporator; FD: floater/dissolver; FE: floater/evaporator; FED: floater/evaporator/dissolver; Fp: persistent floater; SD: sinker/dissolver
- Values collected from the literature and public databases e.g. PubChem
- “-“ corresponds to values not found
- Values estimated with models of the EPI suiteTM
Fugacity/Persistence
-
0.00
Air
4, 5 -
98.70
Water
4, 5 -
0.01
Soil
4, 5 -
1.29
Sediment
4, 5 -
14.4
Persistence (days)
4
- Values estimated with models of the EPI suiteTM
- In the present study, only emissions in water were considered
Physicochemical degradation/Biodegradation
-
1.5
Atmosferic Oxidation (hours)
4 -
R
Biodegradation rate (GESAMP, 2016)
6, 7 -
0.66
Aerobic biodegradation probability
4 -
3.66 days-weeks
Primary aerobic biodegradation half-life
4, 8 -
2.94 weeks
Ultimate aerobic biodegradation half-life
4, 8 -
-
Hydrocarbon Biodegradation half-life (days)
3, 4 -
0.16
Anaerobic Biodegradation probability
4
- “-“ corresponds to values not found
- Values estimated with models of the EPI suiteTM
- Results obtained from the literature
- GESAMP criteria consider substances to be “readily biodegradable” (R) if, in 28-day biodegradation studies, the following levels of degradation are achieved: in tests based upon dissolved organic carbon (DOC) die-away: ≥ 70%; or in tests based upon oxygen depletion or carbon dioxide generation: ≥ 60% of the theoretical maxima; or where only chemical oxygen demand (COD) and biochemical oxygen demand (BOD5) data are available, the ratio of BOD5/COD ≥ 0.5; or where other convincing scientific evidence is available to demonstrate that the substance can be degraded (biotically and/or abiotically) in the aquatic environment to a level of > 70% within a 28-day period. Otherwise they are “not readily biodegradable” (NR) (GESAMP, 2014).
- See Table 1 in the supplementary material for more information on the rating reported by Boethling et al. (1994)
Bioaccumulation/Biotransformation
-
0.11
Biotransformation half-life (days)
2 -
1.96
Partition coefficient (log Kow)
2 -
7.7
Bioconcentration factor (BFC)
4 -
2
Bioaccumulation rate (GESAMP, 2016)
9 -
2.33
Adsorption coefficient (log koc)
2
- Values collected from the literature and public databases e.g. PubChem
- Values estimated with models of the EPI suiteTM
- See Table 2 in the supplementary material for more information on Bioaccumulation rate classification (GESAMP, 2014)
Aquatic Toxicity
-
3
Acute toxicity (GESAMP, 2016)
10 -
1
Chronic toxicity (GESAMP, 2016)
3, 10
- “-“ corresponds to values not found
- See Table 3 in the supplementary material for more information on Aquatic Toxicity classification (GESAMP, 2014)
Acute Mammals/Human health effects
-
2
Oral Toxicity (GESAMP, 2016)
11 -
2
Dermal toxicity (GESAMP, 2016)
11 -
4
Inhalation toxicity (GESAMP, 2016)
11 -
3A
Skin irritation & corrosion (GESAMP, 2016)
11 -
3
Eye irritation & corrosion (GESAMP, 2016)
11 -
8
Toxicity
12 -
12
Severity
12
- See Table 4 in the supplementary material for more information on Human health (Toxic effects to mammals) classification (GESAMP, 2014)
- For more information on Toxicity and Severity scores consult Harold et al. (2014)
Chronic Human/Mammals health effects
-
2
Carcinogenicity (IARC)
3, 13 -
No
Mutagenicity (GESAMP, 2016)
11 -
No
Reprotoxicity (GESAMP, 2016)
11 -
No
Sensitizing to skin (GESAMP, 2016)
11 -
No
Aspiration hazard (GESAMP, 2016)
11 -
No
Target Organ Toxicity (GESAMP, 2016)
11 -
No
Sensitizing to respiratory system (GESAMP, 2016)
11 -
No
Neurotoxicity (GESAMP, 2016)
11 -
No
Immunotoxicity (GESAMP, 2016)
11
- “-“ corresponds to values not found
- See Table 4 in the supplementary material for more information on Human health (Toxic effects to mammals) classification (GESAMP, 2014)
- See Table 5 in the supplementary material for more information on IARC classification
Toxicity tests results
PNECseawater:
0.89 µg/L
PNECwater, intermittent:
89 µg/L
Algae
-
EC50
Parameter
1 -
27.514
Concentration
(mg/L) -
Green algae
Species
-
-
Endpoint
-
Freshwater; 96h-exposure
Observations
1
- Values predicted with ECOSAR V1.11 (EPA) (accessed February 7, 2017)
Invertebrates
-
EC50
Parameter
1 -
30
Concentration
(mg/L) -
Green sea urchin - Strongylocentrotus droebachiensis
Species
-
Effect on development
Endpoint
-
Saltwater; Static; 5 °C; 96h-exposure; Eggs (fertilized)
Observations
2
-
EC50
Parameter
2 -
19.25
Concentration
(mg/L) -
Water flea - Daphnia magna
Species
-
Intoxication; immobilization
Endpoint
-
Freshwater; Static; 20 ºC; 24h-exposure; < 72h age
Observations
3
-
LC50
Parameter
3 -
8.9
Concentration
(mg/L) -
Water flea - Daphnia magna
Species
-
Intoxication; immobilization
Endpoint
-
Freshwater; Static; 20-22 °C; 24h-exposure; ≤ 24h age
Observations
4
-
LC50
Parameter
4 -
18.8
Concentration
(mg/L) -
Water flea - Daphnia magna
Species
-
Mortality
Endpoint
-
Freshwater; 48h-exposure
Observations
5
- Falk-Petersen IB et al; Sarsia 70: 11-16 (1985) as cited in the ECOTOX database. Available at: https://cfpub.epa.gov/ecotox/quick_query.htm (accessed February 6, 2017)
- Devillers J; Sci Total Environ 76 (1): 79-83 (1988) as cited in the ECOTOX database. Available at: http://cfpub.epa.gov/ecotox/quick_query.htm (accessed February 6, 2017)
- Bringmann G, Kuhn R; TR-79-1204, Literature Research Company, Annandale, VA: 26 p. (1977) as cited in the ECOTOX database. Available at: https://cfpub.epa.gov/ecotox/quick_query.htm (accessed February 15, 2017)
- Parkhurst BR et al; Bull Environ Contam Toxicol 23 (3): 349-356 (1979) as cited in the ECOTOX database. Available at: https://cfpub.epa.gov/ecotox/quick_query.htm (accessed January 25, 2017)
Fish
-
LC50
Parameter
1 -
10
Concentration
(mg/L) -
Bluegill - Lepomis macrochirus
Species
-
Mortality
Endpoint
-
Freshwater; 96h-exposure
Observations
6
-
LC50
Parameter
2 -
8.9
Concentration
(mg/L) -
Rainbow trout - Oncorhynchus mykiss
Species
-
Mortality
Endpoint
-
Freshwater; Flow through; 14 ºC; 96h-exposure
Observations
7
Lowest
-
LC50
Parameter
2 -
55.9
Concentration
(mg/L) -
Fathead minnow - Pimephales promelas
Species
-
Mortality
Endpoint
-
Freshwater; Flow through; 14 ºC; 96h-exposure
Observations
8
- Verschueren K; Handbook of Environmental Data on Organic Chemicals. Volumes 1-2. 4th ed. John Wiley & Sons, New York, NY. (2001)
- DeGraeve GM et al; Arch Environ Contam Toxicol 9 (5): 557-568 (1980) as cited in the ECOTOX database. Available at: http://cfpub.epa.gov/ecotox/quick_query.htm (accessed February 6, 2017)
Mammals
-
LD50
Parameter
1 -
2010
Concentration
(mg/kg) -
Mouse
Species
-
Mortality
Endpoint
-
Acute; intravenous
Observations
9
-
LD50
Parameter
2 -
828
Concentration
(mg/kg) -
Mouse
Species
-
Mortality
Endpoint
-
Acute; oral
Observations
10
-
LD50
Parameter
2 -
242
Concentration
(mg/kg) -
Rat
Species
-
Mortality
Endpoint
-
Acute; oral
Observations
11
-
LD50
Parameter
1 -
1100
Concentration
(mg/kg) -
Rat
Species
-
Mortality
Endpoint
-
Acute; dermal
Observations
12
-
LD50
Parameter
1 -
280
Concentration
(mg/kg) -
Rabbit
Species
-
Mortality
Endpoint
-
Acute; intravenous
Observations
13
- NIOSH; Criteria Document: Cresol (1978) DHEW Pub. NIOSH 78-133
- Lewis RJ Sr; Sax's Dangerous Properties of Industrial Materials. 11th ed. Wiley-Interscience, Wiley & Sons, Inc., Hoboken, NJ. (2004)
References
Boethling RS, Howard PH, Meylan W, Stiteler W, Beauman J, Tirado N. 1994. Group contribution method for predicting probability and rate of aerobic biodegradation. Environ. Sci. Technol. 28: 459-465.
Bonn Agreement, 1994. European Classification System, Bonn Agreement: Counter-Pollution Manual. Bonn Agreement, London (Chapter 25).
GESAMP (IMO/FAO/UNESCO-IOC/WMO/WHO/IAEA/UN/UNEP Joint Group of Experts on the Scientific Aspects of Marine Environmental Protection), 2014. Revised GESAMP Hazard Evaluation Procedure for Chemical Substances Carried by Ships, 2nd edition. Rep. Stud. GESAMP No. 64, 126 pp.
GESAMP Composite List, 2016. ANNEX 5 – UPDATED GESAMP COMPOSITE LIST. Available at: https://edocs.imo.org/Final Documents/English/PPR 1-CIRC.3 (E).docx (Accessed: December 12, 2016).
Harold PD, Souza AS, Louchart P, Russell D, Brunt H, 2014. Development of a risk based prioritisation methodology to inform public health emergency planning and preparedness in case of accidental spill at sea of hazardous and noxious substances (HNS). Environ. Int. 72: 157-163.