Technology Offers


CIIMAR follows a market-driven approach to support the development of a sustainable blue economy while tackling important societal challenges. Through the implementation of Large-Scale Mobilizing R&TD Programs and R&D projects in co-promotion with companies, the Centre promotes the transfer of knowledge, fostering the development of new technologies, products and services with a strong innovation component, transforming research results into economic and social value.

CIIMAR is a founding member of the National Blue Economy Cluster – Fórum Oceano, the BlueBio Alliance – BBA, and the Blue Bioeconomy Collaborative Laboratory – B2E CoLAB.

Technology offers

Here are listed all the technologies available for cooperation opportunities, from licensing to other partnerships.

Want to know more about our available technologies? Please contact CIIMAR´s  Technology Transfer and Business Development Office.

Technology offer

Method for obtaining proteins or rich-protein extract from algae

This technology relates to novel methods for disrupting algae cell walls based on milling and enzymatic lysis obtaining a high nutrient digestibility protoplast to be used as a functional feed or food ingredient in human or animal diets. 

Algae nutrient bioavailability
Novel ingredients
Cell wall disruption
Digestive enzymes

Technology offer

Autonomous aquaculture fish feeding system and operation method thereof

This technology relates to an autonomous aquaculture fish feeding system and method, comprising an autonomous vessel with a plurality of temperature and salinity sensors and an electronic data processor configured for calculating a fish weight prediction model from collected temperature and salinity data.

Smart Systems
Predictive Feeding
Modelling and Simulation
Autonomous Vessels

Technology offer

Antimalarial agent, methods and use thereof

This invention relates to halogenated alkyl-aromatic secondary metabolites, in particular hierridin C and its application as an antimalarial and anticancer agent. Furthermore, this technology relates to methods to obtain this novel compound from the cyanobacterium Cyanobium sp. LEGE 06113 and to methods to chemically synthetize it under laboratory conditions.

Hierridin C
Halogenated Alkyl-aromatic

Technology offer

Sporeforming probiotic strains, methods and uses thereof

This technology relates to the isolation, identification and characterization of novel sporeforming probiotic strain(s) with NSPase (Non-Starch Polysaccharides-active hydrolases) activity isolated from fish gut microbiota, methods and uses thereof.

Non-Starch Polysaccharides
Fish gut bacteria

Technology offer

Device for capturing in situ aquatic microbiomes

This invention relates to a portable device for collecting and/or concentrating in situ plankton microbiome, configured for submersion in water. The is a compact and low-cost autonomous biosampler, with the ability to yield DNA samples for later genomic analysis.

Autonomous Biosampler
In situ observation
Plankton monitoring
Water microbiome
Environmental DNA

Technology offer

Xanthonic compounds and their use as antifouling agents

The present invention provides an eco-friendly solution to the naturally-occuring bio-adhesion of macrofouling organisms, on submerged surfaces by using small synthetic xanthonic derivatives as antifouling agents.

Copper-free coatings
Submerged surfaces
Eco-friendly agents

Technology offer

Antimicrobial pyrazino [1,2-b]quinazoline-3,6-diones derivatives and their production

This invention relates to pyrazino [1,2-b] quinazoline-3,6-diones compounds, in particular it relates to pyrazino [1,2-b] quinazoline-3,6-diones compounds having antibacterial activity and/or antimalarial activity. The invention encompasses the synthesis and the use of synthetic pyrazino [1,2-b]quinazoline-3,6-diones derivatives, inspired by complex marine compounds with antimicrobial properties.

Antibacterial agent
Antimalarial agent
Drug discovery
Plasmodium falciparum
Staphylococcus aureus

Technology offer

New hydrolysates to control infections, methods and uses thereof

This invention relates to a method to obtain a new hydrolysate, and uses thereof. Namely an extract from blood hydrolysate (BH), this new extract may be used as a food supplement in aquafeeds to promote fish robustness and control bacterial infections. The extract or composition of the present disclosure may be used in medicine or veterinary, namely in in the prevention or treatment of Tenacibaculum maritimum infections.

Blood hydrolysates
Food supplement
Bacterial infections

Technology offer

New cationic steroid with antimicrobial properties method and uses thereof

The present invention relates to cationic steroid compounds of formula (I) and methods of obtaining them. The present invention further relates to the incorporation of such compounds in a polymeric matrix composition or a coating composition, as well as their use as antimicrobials.


Technology offer

Antifouling Compound, method and uses thereof

The present disclosure relates to a synthetic antifouling compound, compositions, methods and uses thereof.
The present disclosure further relates to the use of said compound as antifouling agent and compositions thereof, such as coatings and/or paints for surface protection of underwater surfaces.

Copper-free coatings
Surface integrity
Eco-friendly agents

Technology offer

Use of napyradiomycins with anti-fouling activity and compositions thereof

This application describes the use of compounds belonging to the napyradiomycin family to inhibit the fouling of marine micro- and macro-organisms on surfaces in contact with water, without compromising the viability of the organisms. these compounds prevent the fouling of different marine organisms and have a low harmful effect on marine ecosystems. In this way, these compounds can be used in paint, varnish, primer and sealant compositions for surfaces in contact with water, as anti-fouling agents, and as an advantageous alternative to the use of biocides including copper compounds.

Natural compounds

Technology offer

Ultra-violet absorbing compounds

The present application relates to novel compounds able to absorb UV radiation and comprise antimicrobial properties as well. The compounds herein described are novel and undisclosed scytonemin analogs, able to absorb up to 90% of UV-A radiation and can cover a broader UV to blue light absorption range from 293 nm to 500 nm. When mixtures of more than one compound are used, their synergetic absorption properties can cover an even broader spectrum within 293 nm to 500 nm. The compounds described present faint coloration, and some are even colorless, therefor the present compounds can be easily incorporated in formulations to be used in cosmetic products, sunscreens or lenses for sunglasses.

Natural UV filters
Ultra-violet (UV) radiation
Cosmetic products

Technology offer

Hydroxypheophorbide compounds, methods and uses thereof

The present disclosure relates to hydroxypheophorbide compounds with bioactivities towards obesity and obesity-related co-morbidities. Therefore, the present subject-matter discloses hydroxypheophorbide compounds or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide, stereoisomer, diastereoisomer, enantiomer or atropisomer, polymorph for use in medicine comprising formula (I), wherein R is CnH(2n-1) and n is an entire number multiple of 5. The compound of the present disclosure may be use in the therapy or treatment of obesity, an obesity-related disorder, an obesity related disease, being overweight, an obesity-related condition, or lipid obesity disorders.

Marine biotechnology
Lipid metabolism

Technology offer

Halogenated compounds, process and uses thereof

The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

Medical devices
Natural compounds

Technology offer

Teleost fish larval diets supplemented with natural extracts for promoting fish growth performance

The present invention relates to teleost fish larval diets supplemented with natural extracts of curcumin, green tea and grape seed and to a method for improving fish growth performance by providing these diets to fish during the larvae and post-larvae phases. Growth of fish is directly dependent on feed composition and quality. Inclusion of plants extracts in fish diets can promote multiple functional physiological changes that includes antioxidant, and anti-inflammatory responses, of curcumin (CC), green tea (GT) and grape seed (GS) as dietary supplements. The present invention is thus in the field of aquaculture, nutrition, and preparation of marine fish larval diets.

Fish larval diets
Natural extracts
Growth performance

Technology offer

Cold extruded diet formulation for sea urchins

The present disclosure relates to the formulation of dry and stable cold extruded diets for sea urchins. More specifically, diets to improve the growth and color of the gonads of the species Paracentrotus lividus. The diets can significantly increase the economic value of P. lividus by increasing the size of the gonads and improving their color. One aspect of the present disclosure relates to a cold-extruded diet formulation for sea urchins comprising 20 – 300 mg/kg of carotene as a pigment.

Cold extruded diet
Echinoderm aquaculture
Sea urchin

Technology offer

Enzyme-rich extract and use thereof in pre-treatment of plant feedstuff-based diets

The present disclosure relates to an enzyme-rich extract obtained through solid-state fermentation (SSF) of Brewer’s Spent Grain (BSG) to be used as a feed additive in animal diets, preferably fish diets. The present patent application also discloses a pre-treatment process of plant feedstuff-based (PF) diets in order to increase the nutrient bioavailability of said diets, thus increasing their nutritional value.

Feed supplement
Brewery spent grain
Solid-state fermentation

Technology offer

Bioactive compounds obtained from cyanobactera leptothoe sp. Lege 181152

A presente invenção refere-se a compostos bioactivos obtidos a partir da estirpe da cianobactéria Leptothoe sp. LEGE 181152. Os compostos obtidos a partir do extrato orgânico desta cianobactéria são o arabinosídeo de hipoxantina, a 2′-deoxiinosina e o formidolídeo D. Verificou-se que estes compostos têm atividade citotóxica contra células cancerígenas. Além disso, os compostos agora divulgados também têm atividade anti-incrustante contra organismos marinhos macro e microincrustantes.

Eco-friendly coatings
Natural products

Technology offer

Protein carrier system based on cyanobacterial nano-sized extracellular vesicles

The present invention refers to a genetic construct for carrying a protein of interest in cyanobacterial extracellular vesicles (EVs) of Synechocystis sp. PCC6803. The present invention further relates to the derived transformed Synechocystis strain comprising the said construct. Cyanobacterium transformed with referred construct are, most surprisingly, further characterized by hypervesiculating EVs to larger extents than the wild-type and mutant strains known in the art. Cyanobacterium transformed with the referred construct secrete the protein of interest in EVs and to the extracellular medium thus, the present invention also refers to compositions comprising EVs derived from the said transformed Synechocystis strain, as well as compositions comprising the EV-free extracellular medium derived from the said transformed Synechocystis strain, for use in carrying proteins proteins/enzymes into animals, including mammals and fish. The present invention further refers to methods for transforming mammalian epithelial cells with EVs isolated from the said Synechocystis strain, which internalize the said EVs and display the protein of interest. Moreover, the present invention refers to methods by which cyanobacterial EVs can work as nanocarriers of custom proteins into fish, with prospective applications in modulation of nutritional status or stimulating specific adaptive immune responses. The construct, strain, compositions uses and methods in the present invention may be advantageously employed as a novel biotechnological tool for the specific delivery of biologically active proteins and enzymes in biotechnology in general and in aquaculture in specific.

Extracellular vesicles
Antigen delivery