Miguel Santos is a professor at the Department of Biology of the Faculty of Sciences of the University of Porto and the head of the Endocrine Disruptors and Emerging Contaminants Team at CIIMAR. He received his PhD in 2002 in Biology from FCUP-University of Porto with a joint supervison at the Netherlands Institute for Sea Research (NIOZ). His research interests focus on the hazard assessment of endocrine disrupting chemicals and other priority and emerging contaminants.
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This project stands at the forefront of environmental epigenetics by addressing a critical limitation in the field: the lack of precise tools to study transgenerational epigenetic inheritance. By applying CRISPR technology in zebrafish, it introduces a robust and scalable model for investigating how environmental chemicals induce heritable changes, fundamentally improving risk assessment frameworks. Moreover, the project’s interdisciplinary nature—combining molecular biology, toxicology, and epigenetics—ensures a comprehensive approach to understanding environmental stressors’ long-term impact. Ultimately, this research will not only advance our knowledge of epigenetic inheritance but also pave the way for innovative strategies in ERA. Given the relevance of epigenetic modulation in several areas, the findings are expected to have broader implications also in fields like health sciences, evolutionary biology and conservation and aquaculture.
