My group is interested in the bioactivity screening and elucidation of molecular mechanism of natural products from aquatic ecosystems (freshwater, estuarine, marine). Here, we use a combination of phenotypic assays and physiologically relevant screening models, namely zebrafish larvae or advanced cell culture techniques.
The focus is to discover novel natural products for metabolic diseases (obesity, diabetes, steatosis).
The main organism will be cyanobacteria, actinobacteria, microalgae or macroalgae, but also other marine organism. Proof of concept of promising compounds will be done in relevant disease models, in particular using the zebrafish model, and the molecular mechanism of action will be deciphered by applying various molecular methodologies. The aim of this group is the valorization of aquatic/marine resources for human diseases, and in particular for metabolic diseases.
Ralph Urbatzka is a principal researcher at CIIMAR, and team leader of “Biodiscovery for Health”. He graduated in Biology in 2002 in Cologne, Germany and received his PhD in 2007 in Molecular Biology from the Humboldt-University Berlin, Germany. His current research interests focus on the bioactivity screening and elucidation of molecular mechanism of natural products from aquatic ecosystems, in particular for metabolic diseases.
Catarina Gonçalves holds a Pharmacy BSc from School of Health of Polytechnic Institute of Porto (ESS. PPorto) and a Pharmaceutical Chemistry MSc from Faculty of Pharmacy of the University of Porto. She is currently PhD student in Marine Biotechnology and Aquaculture in the Faculty of Sciences – University of Porto. Her PhD research focus on finding novel bioactive compounds produced by cyanobacteria with different biotechnological applications (health, cosmetics and environemtal).
Diogo Ferreira Martins earned a B.Sc. in General and Aquatic Biology from the University of Porto in 2011. He received a Fulbright Research Grant in 2013 for studying migratory fish physiology at the US Geological Survey, MA, USA. He obtained a Ph.D. in Animal Science in 2016 from the University of Porto and was a Postdoctoral Research Associate at the University of Massachusetts, MA, USA in 2017. Diogo specializes in molecular physiology and endocrinology, and he is currently a researcher in the Biodiscovery for Health (B4H) group conducting research focused on the exploration of cyanobacteria/microalgae for biotechnological and biomedical research.
Degree in Biochemistry (Porto), Master in Applications in Biotechnology and Synthetic Biology (Porto) and with skills and experience in entrepreneurship acquired in the HiTech 2022 programme. I did an internship in the area of Blue Biotechnology, namely the isolation of bioproducts for human health of economic interest and respective testing in model animals, in a business context at Fykia Biotech Lda., spin-off of CIIMAR.
My passion for the ocean led me to study a bachelor’s degree on marine sciences in the University of Las Palmas de Gran Canaria (ULPGC) and I´m currently complementing it with a master´s degree on Applied Blue Biotechnology in the Catholic University of Valencia (UCV). Along my studies, I developed a growing interest on Marine Natural Products which took me to form part on the “IslandAp” project in the ITC-Canarias institution. Nowadays, the CIIMAR institution opened their arms hosting me in an internship on the research of appetite reducing compounds from microalgae extracts with Ralph Urbatzka as the team leader.
Leonor Ferreira holds a Bachelor’s degree in Environmental Sciences and Technology from FCUP and a Master’s degree in Environmental Toxicology and Contamination from ICBAS/FCUP. She worked as a research fellow for project CYANCAN, performing bioactivity screening of cyanobacteria extracts and isolation of new bioactive compounds. Currently, she is a PhD student in Marine Biotechnology and Aquaculture from FCUP. Her work focuses on the prospection of cyanobacteria for isolating new bioactive compounds. Her main research interests are 3D cancer cell models, multidrug resistance, drug discovery and natural products from cyanobacteria.
Ana Rita Pais, with BSc and MSc in Biochemistry, is currently a Biochemistry PhD student at University of Aveiro, in collaboration with CIIMAR and CBQF. The main focus of her PhD are the evaluation of the bioaccessibility and bioavailability of different microalgae’s biomass and lipid extracts, the characterization the lipid profile of bioacessible and bioavailable fractions using lipidomics approach, and the evaluation of bioactive potential of these fractions.
Sofia Correia is a PhD student, currently enrolled in the Biomedical Sciences doctoral program at the School of Medicine and Biomedical Sciences of the University of Porto. Sofia’s research focus in to investigate Actinobacteria from two highly underexplored environments, deep sea and karst caves, for the discovery of new bioactive compounds with pharmacological relevance. Sofia holds a BSc in Biochemistry (2019, UTAD) and a MSc in Biochemistry (2021, FCUP-ICBAS, UP).
Regueiras, A, Huguet, Á, Conde, T, Couto, D, Domingues, P, Domingues, MR, Costa, AM, Silva, JLd, Vasconcelos, V, Urbatzka, R.
2022Mar. Drugs, 20, 9Bellver, M.; Costa, S.L.d.; Sanchez, B.A.; Vasconcelos, V.; Urbatzka, R.
2021Mar. Drugs, 19, 161Sousa M.L., Ribeiro T., Vasconcelos V., Linder S., Urbatzka R.
2020Toxicon, 175: 49-56Sousa M.L., Preto M., Vasconcelos V., Linder S., Urbatzka R.
2019Frontiers in Oncology, 9 (APR)Freitas S., Silva N.G., Sousa M.L., Ribeiro T., Rosa F., Leão P.N., Vasconcelos V., Reis M.A., Urbatzka R.
2019Marine Drugs, 17 (4)