Development of oral probiotic-based vaccines for sustainable disease control in aquaculture

Disease outbreaks are among the major challenges threatening aquaculture sustainability worldwide. Traditional disease control strategies, such as antibiotics and immersion vaccines, present limitations related to resistance, environmental impact, and practicality. Oral vaccination represents a promising, welfare-friendly alternative; however, developing effective delivery systems remains a challenge. This presentation introduces an innovative approach using Bacillus subtilis spores as carriers for oral probiotic-based vaccines. By displaying specific antigens on the spore surface, these bioengineered probiotics can elicit protective immune responses while simultaneously promoting gut health. This dual action supports both disease prevention and microbiota balance. The talk will highlight recent advances and the potential of this strategy as a sustainable solution for controlling bacterial diseases in aquaculture.

Jorge García Márquez (CIIMAR)

Jorge García Márquez is a dedicated fish microbiologist focused on developing innovative and sustainable solutions for disease prevention in aquaculture. His research explores alternative functional ingredients—including algae, probiotics, and postbiotics—to enhance fish immunity and gut health. By integrating microbiology, immunology, and biotechnology, he aims to reduce antibiotic dependence and promote environmentally friendly strategies that strengthen fish resilience and support the long-term sustainability of modern aquaculture systems.

In case of any questions, please contact CIIMAR’s Seminar team, Marta Monteiro, Miguel Semedo, & Paulo Oliveira, at seminars@ciimar.up.pt

External members of CIIMAR should send an email to slopes@ciimar.up.pt, requesting authorization to enter the Porto Cruise Terminal area

CIIMAR members can also access last seminars recordings through the LINK.