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National R&D

PROPELLER

Investigation of a new class of beta-propeller enzymes

Principal Investigator
Team Leader

Pedro Leão is Principal Investigator and ERA Chair Holder in Blue Biotechnology and Bioengineering at CIIMAR, where he leads the Research Line in Marine Biotechnology and is the head of the Research Group “Cyanobacterial Natural Products”. He graduated in Biochemistry from the University of Porto in 2005 and went on to receive his MSc (2006) and PhD (2010) degrees from the same university. He undertook postdoctoral studies at CIIMAR, Scripps Institution of Oceanography and Harvard University. He became an “FCT Investigator” in 2015 and started his group at CIIMAR in 2018 after receiving an ERC Starting Grant. His research focuses on the chemistry, biosynthesis and chemical ecology of cyanobacterial natural products.

RESEARCH TEAMS:

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PROPELLER builds on the recent discovery, by our group, of an unprecedented enzymatic reaction catalyzed by a cyanobacterial enzyme – BrtB. This beta-propeller enzyme can use a wide range of fatty acid carboxylates as nucleophiles in an esterification reaction with secondary alkyl halides.

PROPELLER will explore the diversity of BrtB homologs found among cyanobacterial genomes for additional new reactivities. Furthermore, because biosynthetic gene clusters encoding BrtB homologs are virtually unexplored, PROPELLER will use these clusters to guide the discovery of natural products with novel scaffolds.

Leader Institution
CIIMAR-UP
Program
FCT
Funding
Other projects